Product Description The past decade has seen remarkable advances in understanding the workings of the brain, and an essential part of that progress has resulted from important discoveries about signal transduction. Research in neuroscience has led to new insights into the relation between affective disorders and neural signaling. That research has not been widely integrated with clinical psychiatry, however, and until now a comprehensive presentation of research findings has not been published. This monograph brings together in one volume a review of the work of Japanese scientists in the fields of basic and clinical neuroscience. The papers compiled here are from the Symposium on Affective Disorders and Neuronal Signal Transduction and from the 11th Sapporo Neuroscience Meeting, both held in Sapporo, Japan, in 1996. The result is a comprehensive view of signal transduction in the brain and the pathophysiology of affective disorders as well as a review of the mechanisms of antidepressants.