Treatment of malignant glioma remains a major challenge for neurosurgeons, neurologists, medical oncologists, and radiation oncologists caring for patients with these tumors. Glioblastoma multiforme, the most common type of brain tumor, is also the most deadly -- only five percent of patients or fewer will be alive at five years after diagnosis. This comprehensive new reference is edited by a renowned team consisting of a neurosurgeon, medical oncologist, oncologic surgeon, and radiation oncologist. The book provides basic researchers and clinicians with a contemporary review of the epidemiology, diagnosis, and treatment of glioblastoma multiforme, and also imparts to experienced investigators outside of the field sufficient background to apply their skills to the treatment of this deadly disease. Expert malignant glioma researchers and clinicians provide state-of-the-art chapters on important topics such as molecular genetic classification of glioblastoma, surgical management, stem cell therapy, chemotherapy, angiogenesis, and more. Table of Contents Chapter 1. Astrocyte Differentiation States and Glioma Formation; Chengkai Dai, Eric Holland Chapter 2. Classification of Glioblastoma Multiforme in Adults by Molecular Genetics; Ramsis Benjamin, Joanna Capparella, Alice Brown Chapter 3. FAK Signaling in Anaplastic Astroctoma and Glioblastoma Tumors; Meera Natarajan, Timothy P. Hecker, Candece L. Gladson Chapter 4. Angiogenesis in Glioma: Molecular Mechanism